Renal Concentrating Mechanism: Possible Role for Sodium-Potassium Activated Adenosine Triphosphatase

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Science  22 Aug 1969:
Vol. 165, Issue 3895, pp. 807-808
DOI: 10.1126/science.165.3895.807


Sodium-potassium activated adenosine triphosphatase activity was found to be almost twice as high in renal medulla as in cortex. Infusion of digoxin, a specific inhibitor of the enzyme, into one renal artery of the dog resulted in unilateral natriuresis, impaired concentrating capacity, and reduction of the enzyme activity in both cortex and medulla. It is suggested that the sodium-potasium adenosine triphosphatase plays an important role in urine concetration mechanisms.

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