Quantal Secretion from Adrenal Medulla: All-or-None Release of Storage Vesicle Content

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Science  29 Aug 1969:
Vol. 165, Issue 3896, pp. 911-913
DOI: 10.1126/science.165.3896.911


Neurogenic secretion of catecholamines from the adrenal medulla in rabbits, induced by administration of insulin, caused decreases in both the dopamine-β-hydroxylase activity and the catecholamine content of the storage vesicle fraction. After sedimentation through a sucrose density gradient, the storage vesicles obtained from insulin-treated animals had the same density and the same ratio of dopamine-β-hydroxylase to catecholamine as did vesicles from untreated animals. These and other data indicate that neurogenic secretion from the adrenal medulla occurs by an all-or-none release from the storage vesicles.

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