Hormonal Stimulation of Lactose Synthetase in Mammary Carcinoma

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Science  05 Sep 1969:
Vol. 165, Issue 3897, pp. 1013-1014
DOI: 10.1126/science.165.3897.1013


A transplantable rat mammary carcinoma (R3230AC) synthesizes significant quantities of the mammary gland enzyme lactose synthetase in the immature virgin female rat. In this hormonal environment, mammary glands do not synthesize the enzyme. Prolactin further stimulates the enzyme activity in the tumors to levels found only in mammary glands of rats in late pregnancy or during lactation.

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