Cyclic Adenosine Monophosphate: Possible Mediator for Norepinephrine Effects on Cerebellar Purkinje Cells

See allHide authors and affiliations

Science  05 Sep 1969:
Vol. 165, Issue 3897, pp. 1018-1020
DOI: 10.1126/science.165.3897.1018


Microelectrophoretic application of norepinephrine or cyclic adenosine monophosphate reduces the discharge frequency of Purkinje cells in the rat cerebellum. In contrast, other nucleotides accelerate the discharge rate of most units. Parenterally administered theophylline, which inhibits the hydrolysis of cyclic adenosine monophosphate enhances the effects of norepinephrine and cyclic adenosine monophosphate. Therefore, norepinephrine may be able to regulate Purkinje cells functionally by metabolic stimulation of cyclic adenosine monophosphate synthesis.

Stay Connected to Science