Infection as the Etiology of Spongiform Encephalopathy (Creutzfeldt-Jakob Disease)

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Science  05 Sep 1969:
Vol. 165, Issue 3897, pp. 1023-1025
DOI: 10.1126/science.165.3897.1023


Fatal spongiform encephalopathy occurred in four chimpanzees 12 to 14 months after inoculation with suspensions of brain from four patients, respectively. Chimpanzee to chimpanzee transmission was effected without reduction in incubation period. Retransmission of the disease to a second chimpanzee occurred when an inoculum that had been stored at —70°C for over 2 years was used.

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