Tumor Induction in Developing Frog Kidneys by a Zonal Centrifuge Purified Fraction of the Frog Herpes-Type Virus

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Science  12 Sep 1969:
Vol. 165, Issue 3898, pp. 1134-1137
DOI: 10.1126/science.165.3898.1134


Injection of frog embryos (Rana pipiens) with a zonal centrifuge purified fraction of herpes-type virus (prepared from virus-containing Lucké tumors) resulted in a high incidence of kidney tumors. This partially purified oncogenic fraction contained a high concentration of an enveloped form of the frog herpes-type virus (adjacent fractions lacked this particle and were not oncogenic), which suggests that this form of the virus plays a role in the genesis of the Lucké tumor.

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