Interferon Induction Increased through Chemical Modification of a Synthetic Polyribonucleotide

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Science  12 Sep 1969:
Vol. 165, Issue 3898, pp. 1137-1139
DOI: 10.1126/science.165.3898.1137


The alternating copolymer riboadenylic-ribouridylic acid gained asignificant increase in ability to stimulate interferon production (2-to 20-fold) and cellular resistance (100-to 10,000-fold) both in vitro and in vivo upon substitution of phosphate by thiophosphate groups. The resulting nucleotide analog was also 10 to 100 times less sensitive to degradation by pancreatic ribonuclease, as determined byresidual antiviral activity.

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