Diphosphonates Inhibit Hydroxyapatite Dissolution in vitro and Bone Resorption in Tissue Culture and in vivo

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Science  19 Sep 1969:
Vol. 165, Issue 3899, pp. 1262-1264
DOI: 10.1126/science.165.3899.1262


Two diphosphonates containing the P-C-P bond, Cl2C(PO3HNa)2, and H2C(PO3HNa)2 retard the rate of dissolution of apatite crystals in vitro. They inhibit bone resorption induced by parathyroid extract in mouse calvaria in tissue culture and in thyroparathyroidectomized rats in vivo.

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