Toxin from Skin of Frogs of the Genus Atelopus: Differentiation from Dendrobatid Toxins

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Science  26 Sep 1969:
Vol. 165, Issue 3900, pp. 1376-1377
DOI: 10.1126/science.165.3900.1376


A potent, dialyzable toxin (atelopidtoxin) occurs in the skin of frogs of the genus Atelopus. A concentrate of atelopidtoxin from Atelopus zeteki has an LD50 in mice of 16 micrograms per kilogram. It differs from batrachotoxin, tetrodotoxin, and saxitoxin, the only known nonprotein substances of greater toxicity, as well as from all toxins previously isolated from amphibia.

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