Virus of the 1918 Influenza Pandemic Era: New Evidence about Its Antigenic Character

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Science  03 Oct 1969:
Vol. 166, Issue 3901, pp. 117-119
DOI: 10.1126/science.166.3901.117


In serums of unusually isolated Pacific islanders whose only exposure to influenza occurred during the era of the 1918 pandemic the residual neutralizing antibody was greatest to the PR/8 and BH strains of human type A influenza virus, significantly lower to swine influenza virus, and absent to equine or later human type A virus strains. The pandemic virus was thus antigenically closer to human type A strains isolated during the middle 1930's than to other known influenza virus types.

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