Androgen Accumulation and Binding to Macromolecules in Seminal Vesicles: Inhibition by Cyproterone

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Science  10 Oct 1969:
Vol. 166, Issue 3902, pp. 233-235
DOI: 10.1126/science.166.3902.233


Cyproterone reduces the accumulation of testosterone and dihydrotestosterone in seminal vesicles 30 minutes after intravenous administration of tritiated testosterone to castrated rats. Testosterone, added in vitro, binds to macromolecules from the supernatant fraction of the seminal vesicle homogenates; this interaction is antagonized competitively by cyproterone. Cyproterone may diminish androgenic effects by competition for binding molecules.

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