Circadian Periodicity of Bone Marrow Mitotic Activity and Reticulocyte Counts in Rats and Mice

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Science  10 Oct 1969:
Vol. 166, Issue 3902, pp. 236-237
DOI: 10.1126/science.166.3902.236


Mitotic proliferation in the bone marrow of female rats and mice kept under standardized coniditions with light from 6:00 a.m. to 6:00 p.m. exhibited a significant circadian periodicity with the greatest activity occurring from 6:00 a.m. to 12:00 noon. The reticulocyte levels in peripheral blood were highest at 8:00 a.m.

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