Synaptic Current at the Squid Giant Synapse

See allHide authors and affiliations

Science  24 Oct 1969:
Vol. 166, Issue 3904, pp. 510-512
DOI: 10.1126/science.166.3904.510


Transmission in the giant synapse of squid was studied by measuring synaptic currents in the voltage-clamped postsynaptic giant axon. These currents varied linearly with the axon's membrane potential, and showed an intercept on the voltage axis at, or near, the sodium equilibrium potential. The intercept shifted in seawater containing less sodium by even more than the shift in the sodium equilibrium potential. It is concluded that the transmitter at this synapse causes a significant change in the sodium conductance only.

Stay Connected to Science