Antithrombin III: Protection against Death after Injection of Thromboplastin

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Science  24 Oct 1969:
Vol. 166, Issue 3904, pp. 517-518
DOI: 10.1126/science.166.3904.517


Intravenous injection of autologous lipoprotein (thromboplastin) or thrombin produced a lethal, hemorrhagic syndrome in chicken embryos. The embryos could be protected from this fatal result by injection of antithrombin III, an alpha2-globulin (molecular weight 60,000 to 80,000) purified from human, bovine, and guinea pig blood. Heparin also protected the embryos, but other inhibitors were less protective.

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