Cyclic Adenosine Monophosphate: Stimulation of Melatonin and Serotonin Synthesis in Cultured Rat Pineals

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Science  24 Oct 1969:
Vol. 166, Issue 3904, pp. 519-520
DOI: 10.1126/science.166.3904.519


Dibutyryl cyclic adenosine monophosphate, like norepinephrine, stimulates the synthesis of labeled melatonin and serotonin from tryptophan labeled with carbon-14 by rat pineals in organ culture. Unlike norepinephrine, dibutyryl cyclic adenosine monophosphate does not enhance the accumulation of labeled tryptophan or protein within the pineal. These findings are compatible with the hypothesis that cyclic adenosine monophosphate mediates some, but not all, of the effects of norepinephrine.

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