Phosphorylation of Dipteran Chromosomes and Rat Liver Nuclei

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Science  31 Oct 1969:
Vol. 166, Issue 3905, pp. 629-631
DOI: 10.1126/science.166.3905.629


Side-chain modifications of the nucleoproteins are believed to be involved in the control of gene function. Rat liver nuclei and chromatin incubated in adenosine triphosphate labeled in the gamma position with phosphorus-32 demonstrated rapid phosphorylation in vitro of the nuclear proteins. Dipteran salivary glands incubated in either labeled adenosine triphosphate or ortho-phosphate labeled with phosphorus-32 showed that there is phosphorylation of chromosomal protein. The phosphorus is associated in protein from both liver and salivary gland nuclei predominantly with phosphoserine.

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