Cortisol Induction of Growth Hormone Synthesis in a Clonal Line of Rat Pituitary Tumor Cells in Culture

See allHide authors and affiliations

Science  31 Oct 1969:
Vol. 166, Issue 3905, pp. 633-634
DOI: 10.1126/science.166.3905.633


Growth hormone synthesis increased markedly after addition of glucocorticoids at physiological concentrations to cultures of the GH1 line of rat pituitary tumor cells. Stimulation of hormone protein synthesis by corticosteroids was selective, since (i) the rate of hormone synthesis increased while total protein synthesis decreased, and (ii) cortisol analogs, biologically inactive metabolites, and sex steroids did not induce growth hormone synthesis.

Stay Connected to Science