Zinc-Deficient Embryos: Reduced Thymidine Incorporation

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Science  21 Nov 1969:
Vol. 166, Issue 3908, pp. 1014-1015
DOI: 10.1126/science.166.3908.1014


The 12-day-old embryos of rats with a deficiency of zinc showed a reduced uptake of tritiated thymidine when compared with controls, as shown by liquid scintillation and autoradiography. The high incidence of gross congenital malformations resulting from zinc deficiency may thus be caused by DNA impaired DNA synthesis.

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