Vascular Smooth Muscle Reactivity in Normotensive and Hypertensive Rats

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Science  05 Dec 1969:
Vol. 166, Issue 3910, pp. 1300-1301
DOI: 10.1126/science.166.3910.1300


Aortic strips from spontaneously hypertensive rats were less responsive than normal animals to the contractile effects of norepinephrine, serotonin, and potassium chloride but more reactive to the relaxant effects of the stimulant of beta receptors, isoproterenol. Thus, hypertension is not the result of an absence of beta receptor or a hypersensitivity of the vascular smooth muscle.

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