Intracranial Drug Implants: An Autoradiographic Analysis of Diffusion

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Science  12 Dec 1969:
Vol. 166, Issue 3911, pp. 1410-1412
DOI: 10.1126/science.166.3911.1410


Labeled crystalline atropine, administered to the hypothlalamus of rats, remainted strictly localized in a sphere, 1.0 to 1.8 millimeters in diameter, ditring the first 3 minutes. A similar distribution obtained after 1 hour. At intermediate times, slightly elevated radioactivity, reflecting concentrations 2,000 to 10,000 times below behaviorally effective doses, was observed several millimeters from the implantation site.

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