m-Hydroxyphenylacetic Acid Formation from L-Dopa in Man: Suppression by Neomycin

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Science  12 Dec 1969:
Vol. 166, Issue 3911, pp. 1417-1418
DOI: 10.1126/science.166.3911.1417


The increased excretion of m-hydroxyphenylacetic acid in the urine of patients with parkinsonism being treated with L-dopa was reduced by gut sterilization with neomycin. The p-de-hydroxylation step is thus brought about solely by the action of gut flora; the pathway is unlikely to be involved in the events within the brain leading to the therapeutic benefit effected by L-dopa.

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