Tobacco Smoke Toxicity: Loss of Human Oral Leukocyte Function and Fluid-Cell Metabolism

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Science  12 Dec 1969:
Vol. 166, Issue 3911, pp. 1424-1428
DOI: 10.1126/science.166.3911.1424


The human mouth has been utilized as a new and significant in vivo open bioassay system for tracing undesirable substances present in tobacco smoke, in an exact milieu where the smoking "problem" begins and must be dealt with directly. The associated in vitro closed test systems described herein have provided new, sensitive bioassays that help to explain the in vivo effects.

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