Avoidance Learning: Long-Lasting Deficits after Temporal Lobe Seizure

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Science  12 Dec 1969:
Vol. 166, Issue 3911, pp. 1435-1437
DOI: 10.1126/science.166.3911.1435


Microinjections of carbachol (carbamylcholine chloride) into the amygdaloid complex of rats produced behavioral and electrophysiological seizures which subsided within 24 hours. A persisting functional change caused a deficit in avoidance learning 1 to 3 weeks after the seizure. A cholinergic system is implicated by the fact that cholinergic blockade (scopolamine) of the amygdala during training reversed the effects of the seizures induced by carbachol.

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