Choroid Plexus and Cerebrospinal Fluid Production

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Science  19 Dec 1969:
Vol. 166, Issue 3912, pp. 1514-1516
DOI: 10.1126/science.166.3912.1514


Acute progressive hydrocephalus occurred in 76 rhesus monkeys undergoing ventricular obstruction 2 to 6 months after choroid plexectomy and was only slightly less pronounced than in 73 nonplexectomized animals with similar ventricular obstructions. The composition of cerebrospinal fluid after choroid plexectomy was essentially normal. Experiments with ventricular perfusion techniques indicate only a slight reduction in cerebrospinal fluid production after choroid plexectomy. Thus, the choroid plexus is probably not tile sole or even the major source of cerebrospinal fluid within the primate ventricular system.

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