Localization of Antigenic Determinants in the Polypeptide Chains of Collagen

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Science  19 Dec 1969:
Vol. 166, Issue 3912, pp. 1522-1523
DOI: 10.1126/science.166.3912.1522


After being injected with collagen from rat or guinea pig skin, rabbits form high titer, species-specific antibodies to collagen. Antibody is directed primarily against the α2 chain of collagen with little reaction With the αl chain. The amino terminal peptide of cyanogen bromide cleavage of the α2 chain of guinea pig skin collagen, α2-CBl, effectively inhibited the antigen-antibody reaction, an indication that a major antigenic determinant of collagen is located at the amino terminal of the α2 chain.

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