Local Anesthetics: Significance of Hydrogen Bonding in Mechanism of Action

See allHide authors and affiliations

Science  19 Dec 1969:
Vol. 166, Issue 3912, pp. 1546-1548
DOI: 10.1126/science.166.3912.1546


The action of local anesthetics is considered in terms of their ability to function as the donor in a hydrogen bond. The formation of a hydrogen-bonded complex between the drug and an acceptor group on the neural membrane is suggested as a feature in the action of local anesthetics.

Stay Connected to Science