Nalorphine: Increased Sensitivity of Monkeys Formerly Dependent on Morphine

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Science  19 Dec 1969:
Vol. 166, Issue 3912, pp. 1548-1549
DOI: 10.1126/science.166.3912.1548


Three rhesus monkeys Macaca mulatta, formerly dependent on morphine, had increased sensitivity to nalorphine's effect of suppressing operant responding for food, as compared with two monkeys with no history of morphine exposure. Within the dose range employed, nalorphine injections produced emesis, salivation, and hyperirritability in formerly morphine-dependent monkeys but not in controls.

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