Mouse Leukemia Virus Activation by Chemical Carcinogens

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Science  26 Dec 1969:
Vol. 166, Issue 3913, pp. 1624-1626
DOI: 10.1126/science.166.3913.1624


The induction of lymphomas in C57BL mice by methylcholanthrene, urethan, or diethylnitrosamine was accompanied by the development of murine leukemia viral antigen in most of the lymphoid tumors. The cell-free transmission of lymphomas induced by methylcholanthrene and the development of antibody to murine leukemia virus prior to the detection of overt lymphoma in these mice suggest that unmasking of a latent leukemia virus is an indigenous actuating cause of the lymphomas.

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