Cytosine to Thymine Transitions from Decay of Cytosine-5-3H in Bacteriophage S13

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Science  26 Dec 1969:
Vol. 166, Issue 3913, pp. 1629-1631
DOI: 10.1126/science.166.3913.1629


Decay of cytosine-5-3H incorporated into bacteriophage S13 DNA causes a molectular rearrangement of the cytosine molecutle undergoing the decay. The molecular rearrangement produces a cytosine to thyimine coding change with at efficiency approaching one. Decay of either thymidine-(methyl)-3H or cytosine-6-3H is less than 1 percent as effective in calusing either cytosine to thymine or thymine to cytosine transitions.

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