L-Asparaginase-Deficient Mutants of Yeast

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Science  09 Jan 1970:
Vol. 167, Issue 3915, pp. 181-182
DOI: 10.1126/science.167.3915.181


Yeast L-asparaginase is a multimeric enzyme for which only a single structural gene has been found. Fourteen mutants deficient in L-asparaginase have been isolated, and they have been located at one site on the genetic map of Saccharomyces cerevisiae. The L-asparaginase gene (aspl) is located about 18 centimorgans from a gene governing tryptophan synthesis (trp4) on fragment 2 of the map.

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