Atropinesterase and Cocaiesterase of Rabbit Serum: Localization of the Enzyme Activity in Isozymes

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Science  09 Jan 1970:
Vol. 167, Issue 3915, pp. 200-202
DOI: 10.1126/science.167.3915.200


Zymograms reveal a multiplicity of esterase isozymes in rabbit serum. Most of the staining activity is concentrated in a region of the gels just anodal to the albumins where six phenotypes (A, AF, F, M, P, and S) are distinguished. The atropinesterase activity is associated with phenotypes A and AF and appears to be restricted to a single isozyme, zone A. Cocainesterase activity is limited to isozyme S, a zone common to all phenotypes except M.

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