Cystic Fibrosis: Characterization of the Inhibitor to Ciliary Action in Oyster Gills

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Science  06 Feb 1970:
Vol. 167, Issue 3919, pp. 871-873
DOI: 10.1126/science.167.3919.871


The inhibitor to oyster ciliary activity was isolated from serumof cystic fibrosis patients and heterozygotes.The inhibitinig protein fraction wast a cation as judged by electrophoresis; it had a molecuer weight of 125,000 to 200,000 as judged by gel filtration; antd oil diethylaminoethyl-cellulose chromatography it eluted with the immunoglobulin G fraction. The analogous fraction in normal individuals did not inhibit oyster cillary activity.

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