Metabolic Dependence of Fast Axoplasmic Transport in Nerve

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Science  06 Feb 1970:
Vol. 167, Issue 3919, pp. 878-879
DOI: 10.1126/science.167.3919.878


Fast axoplasmic transport, shown in cat sciatic nerves by a crest of labeled activity after injection of the L7 ganglion with [3H]-leucine or [ 3H]-lysine, was stopped within 15 minutes after death of the animals by bleeding. If the sciatic nerves were removed from the animals and placed in a chamber supplied with oxygen at 38 degrees centigrade, fast transport was sustained. Transport was rapidly blocked in similar in vitro preparations when the nerves were kept in a nitrogen environment. Fast axoplasmic transport is closely dependent upon oxibdative metabolism.

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