Alanine: Key Role in Gluconeogenesis

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Science  13 Feb 1970:
Vol. 167, Issue 3920, pp. 1003-1004
DOI: 10.1126/science.167.3920.1003


Of 20 amino acids measured, alanine is the principal amino acid released by forearm muscle of man, in accord with its being the principal amino acid extracted by liver for gluconeogenesis. This occurs in both the postabsorptive state and after 4 to 6 weeks of starvation, when total amino acid release is markedly diminished.

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