Proinsulin: Metabolic Effects in the Human Forearm

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Science  13 Feb 1970:
Vol. 167, Issue 3920, pp. 998-999
DOI: 10.1126/science.167.3920.998


Five subjects were studied by the forearm perfusion technique with proinsulin at a final plasma conceintration of 1.76 x 10-9 millimole per milliliter. Two of these subjects were studied with single-component insulin at a concentration of 1.96 x 10-9 millimole per milliliter. Proinsulin is, in general, biologically less potent than single-component insulin. In contrast to insulin, its effects upon adipose tissue are for the most part greater than upon muscle.

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