Pseudohermaphrodite Rat: End Organ Insensitivity to Testosterone

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Science  20 Feb 1970:
Vol. 167, Issue 3921, pp. 1136-1137
DOI: 10.1126/science.167.3921.1136


The pseudohermaphrodite rat is characterized by lack of androgen-dependent differentiation. Treatment of these rats with testosterone failed to produce the expected changes in preputial and adrenal gland weights and hexobarbital metabolism. This insitivity of the end organ to testosterone could not be explained by defective formation of dihydrotestosterone.

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