Penicillin as Epileptogenic Agent: Its Effect on an Isolated Neuron

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Science  27 Feb 1970:
Vol. 167, Issue 3922, pp. 1257-1260
DOI: 10.1126/science.167.3922.1257


Penicillin induces partial depolarization and increased excitability of the neuronal membrane of crayfish stretch receptor. Such effects suggest that the epileptic focus created by the topical application of penicillin to the mammalian cerebral cortex may result from the lowering of the threshold for impluse initiation by excitatory synaptic action within the neuron population.

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