Overgrowth Stimulating Factor Released from Rous Sarcoma Cells

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Science  27 Feb 1970:
Vol. 167, Issue 3922, pp. 1271-1272
DOI: 10.1126/science.167.3922.1271


An assay is described for a nonzviral factor from the medium of Rous sarcoma cells which stimulates rapid and sustained cellular overgrawth in crowded chick embryo cultures. The factor is nondialyzable and thermnolabile and is released in large amounts several days after the first visible transformation of newly infected chick embryo cells.

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