Oncogenic Purine Derivatives: Evidence for a Possible Proximate Oncogen

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Science  20 Mar 1970:
Vol. 167, Issue 3925, pp. 1622-1624
DOI: 10.1126/science.167.3925.1622


Two additional urinary metabolites of the chemical oncogen 3-hydroxyxanthine are now identified as 8-chloroxanthine and 8-methylmercaptoxanthine. Such products are thought to be derived from a reactive intermediate which can be tentatively considered to be a proximate oncogen. Since each of these 8-substituted xanthines has also been obtained in vitro by reactions of 3-acetoxyxanthine with chloride ion or methionine, their production in vivo can be explained as resulting through the metabolic formation of an activated ester with a reactivity similar to that of the chemical model.

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