Alkaloids from Catecholamines in Adrenal Tissue: Possible Role in Alcoholism

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Science  27 Mar 1970:
Vol. 167, Issue 3926, pp. 1749-1751
DOI: 10.1126/science.167.3926.1749


Epinephrine and norepinephrine condensed with acetaldehyde or with formaldehyde in dilute aqueous solution at neutral pH and room temperature to form 1,2,3,4-tetrahydroiso-quinoline alkaloids. Similar condensation reactions occurred in cow adrenal glands perfused with dilute aldehyde solutions at 37°C. Biosynthesis of these alkaloids in vivo could play a role in altering an individual's behavior during and after the ingestion of alcohol.

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