Hyperphenylalaninemia: Disaggregation of Brain Polyribosomes in Young Rats

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Science  03 Apr 1970:
Vol. 168, Issue 3927, pp. 129-130
DOI: 10.1126/science.168.3927.129


A single injection of l-phenzylalanine in 7-day-old rats produtced disaggregation of brain polyribosomties and inhibition of in vitro protein synthesis in cell-free systems prepared from brain. Liver polyribosomes and in vitro protein synthesis in hepatic systems were not affected. In 4-week-old rats these effects on brain protein synthesis did not occur.

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