Cerebral Acid Hydrolase Activities: Comparison in "Quaking" and Normal Mice

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Science  10 Apr 1970:
Vol. 168, Issue 3928, pp. 259-260
DOI: 10.1126/science.168.3928.259


The activity of several acid hydrolase enzymes was determined in whole brain homogenates of adult "quaking" and normal mice. A striking decrease was found in alpha-mannosidase and, to a lesser extent, aryl sulfatase levels in the samples from the mutant animals. The activities of the other "lyso-somal" enzymes were only slightly lowered.

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