Isoantigenic Variants: Isolation from Human Diploid Cells in Culture

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Science  17 Apr 1970:
Vol. 168, Issue 3929, pp. 370-372
DOI: 10.1126/science.168.3929.370


Variant human fibroblast substrains, resistant to a cytotoxic human isoantiserum, were isolated from sensitive strains by repeated exposure to isoantiserum and rabbit complement. The resistant phenotype was stable, apparently occurred at low frequency, and was associated with loss of surface isoantigens.

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