Metobromuron: Acetylation of the Aniline Moiety as a Detoxification Mechanism

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Science  24 Apr 1970:
Vol. 168, Issue 3930, pp. 482-483
DOI: 10.1126/science.168.3930.482


p-Bromoaniline is rapidly acetylated by four soil microorganisms. Two fungal species convert metobromuron to p-bromoacetanilide, but a bacterial and an algal species do not metabolize metobromuron. Acetylation may serve as a detoxification mechanism by competing with azobenzene formation in utilizing the aniline formed by metabolism of substituted urea herbicides.

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