Mediation of Immunity to Tumor Isografts in Mice by Heterologous Ribonucleic Acid

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Science  24 Apr 1970:
Vol. 168, Issue 3930, pp. 492-493
DOI: 10.1126/science.168.3930.492


The growth of tumor isografts in inbred mice is inhibited by intra-peritoneal injections of syngeneic spleen incubated, in vitro, with ribonucleic acid extracted from guinea pigs immunized with the same mouse tumor. This inhibition is partially tumor-specific. Treatment with ribonuclease abolishes the response.

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