Human Glomerular Basement Membrane: Chemical Alteration in Diabetes Mellitus

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Science  01 May 1970:
Vol. 168, Issue 3931, pp. 596-598
DOI: 10.1126/science.168.3931.596


The human glomerular basement membrane belongs to the collagen family of proteins. It contains about 7 percent carbohydrate, half of which occurs as glucosylgalactose disaccharide units linked to hydroxylysine. Glomeruli from diabetics contain increased amounts of basement membrane material. In addition, these membranes show a distict chemical alteration c haracterized by a significant decrease in lysine, accoumpanied by an equivalent increase in hydroxylysine and hydroxylysine-linked disaccharide units.

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