Antagonism by DDT of the Effect of Valinomycin on a Synthetic Membrane

See allHide authors and affiliations

Science  15 May 1970:
Vol. 168, Issue 3933, pp. 841-843
DOI: 10.1126/science.168.3933.841


The potassium conductance which is induced by 10-6 molar valinomycin in a lecithin-decane membrane is reversed by 3 x 10-6 molar DDT. Membranes not treated with valinomycin are not affected by DDT. This blockade of potassium conductance parallels the effect of DDT on axonic conduction. Dieldrin and lindane, whose physiological actions are in some ways like those of DDT, do not affect valinomycin-induced conductance of lecithin-decane membranes.

Stay Connected to Science