Metabolite of (—)-trans-Δ8-Tetrahydrocannabinol: Identification and Synthesis

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Science  15 May 1970:
Vol. 168, Issue 3933, pp. 844-845
DOI: 10.1126/science.168.3933.844


The major metabolite of (—)-trans8-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans8-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans8-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Δ8- and Δ9-tetrahydrocannabinol.

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