Orotidinuria Induced by Allopurinol

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Science  15 May 1970:
Vol. 168, Issue 3933, pp. 861-862
DOI: 10.1126/science.168.3933.861


The administration of allopurinol to patients suffering from hyperuricemia and to normal subjects results in increased excretion of the pyrimidine nucleoside orotidine. Evidence is presented for the interference by allopurinol of the de novo biosynthesis of uridine 5'-phosphate in man.

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