Solution Conformation of Valinomycin-Potassium Ion Complex

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Science  29 May 1970:
Vol. 168, Issue 3935, pp. 1091-1092
DOI: 10.1126/science.168.3935.1091


The complete conformation of the valinomycin-potassium ion complex in methanol is presented. Extension from the reported secondary structure requires arguments and data relating to ester orientation, direction of coiling, side-chain orientation, and conformational stability. Conformation of the valinomycin-potassium ion complex provides a clear-cut example in which elucidation of conformation is sufficient to gain an understanding of molecular function which, in this case, is selective ion transport by a carrier mechanism.